Cloning of a new cytokine that induces IFN-γ production by T cells
@article{Okamura1995CloningOA, title={Cloning of a new cytokine that induces IFN-γ production by T cells}, author={H. Okamura and H. Tsutsui and T. Komatsu and M. Yutsudo and A. Hakura and T. Tanimoto and K. Torigoe and T. Okura and Y. Nukada and K. Hattori and K. Akita and M. Namba and F. Tanabe and K. Konishi and S. Fukuda and M. Kurimoto}, journal={Nature}, year={1995}, volume={378}, pages={88-91} }
THE mechanism underlying the differentiation of CD4+ T cells into functionally distinct subsets (Thl and Th2) is incompletely understood1–3, and hitherto unidentified cytokines may be required for the functional maturation of these cells4. Here we report the cloning of a recently identified IFN-γ-inducing factor (IGIF) that augments natural killer (NK) activity in spleen cells5,6. The gene encodes a precursor protein of 192 amino acids and a mature protein of 157 amino acids, which have no… Expand
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References
SHOWING 1-10 OF 11 REFERENCES
Purification of a factor which provides a costimulatory signal for gamma interferon production.
- Biology, Medicine
- Infection and immunity
- 1993
- 103
- PDF
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
- Biology, Medicine
- Annual review of immunology
- 1989
- 7,624
- PDF
Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology
- Biology, Medicine
- The Journal of experimental medicine
- 1994
- 291
- PDF
Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene
- Biology, Medicine
- The Journal of experimental medicine
- 1989
- 139
- PDF
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4- producing cells
- Biology, Medicine
- The Journal of experimental medicine
- 1990
- 810
- PDF
Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice
- Biology, Medicine
- European journal of immunology
- 1995
- 543
Importance of direct hepatocytolysis by liver macrophages in experimental fulminant hepatitis.
- Medicine
- Hepato-gastroenterology
- 1992
- 28
Rat hepatic sinusoidal endothelial cells in monolayer culture. Biochemical and ultrastructural characteristics.
- Biology, Medicine
- Journal of hepatology
- 1988
- 139
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
- Chemistry, Medicine
- Analytical biochemistry
- 1987
- 64,529