Cloning of a new cytokine that induces IFN-γ production by T cells

@article{Okamura1995CloningOA,
  title={Cloning of a new cytokine that induces IFN-$\gamma$ production by T cells},
  author={Haruki Okamura and Hiroko Tsutsui and Toshinori Komatsu and Masuo Yutsudo and Akira Hakura and Tadao Tanimoto and Kakuji Torigoe and Takanori Okura and Yoshiyuki Nukada and K Hattori and Kenji Akita and Motoshi Namba and Fujimi Tanabe and K Konishi and Shigeharu Okayama-shi Fukuda and Masashi Kurimoto},
  journal={Nature},
  year={1995},
  volume={378},
  pages={88-91}
}
THE mechanism underlying the differentiation of CD4+ T cells into functionally distinct subsets (Thl and Th2) is incompletely understood1–3, and hitherto unidentified cytokines may be required for the functional maturation of these cells4. Here we report the cloning of a recently identified IFN-γ-inducing factor (IGIF) that augments natural killer (NK) activity in spleen cells5,6. The gene encodes a precursor protein of 192 amino acids and a mature protein of 157 amino acids, which have no… 
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