Cloning of a new cytokine that induces IFN-γ production by T cells

@article{Okamura1995CloningOA,
  title={Cloning of a new cytokine that induces IFN-γ production by T cells},
  author={H. Okamura and H. Tsutsui and T. Komatsu and M. Yutsudo and A. Hakura and T. Tanimoto and K. Torigoe and T. Okura and Y. Nukada and K. Hattori and K. Akita and M. Namba and F. Tanabe and K. Konishi and S. Fukuda and M. Kurimoto},
  journal={Nature},
  year={1995},
  volume={378},
  pages={88-91}
}
THE mechanism underlying the differentiation of CD4+ T cells into functionally distinct subsets (Thl and Th2) is incompletely understood1–3, and hitherto unidentified cytokines may be required for the functional maturation of these cells4. Here we report the cloning of a recently identified IFN-γ-inducing factor (IGIF) that augments natural killer (NK) activity in spleen cells5,6. The gene encodes a precursor protein of 192 amino acids and a mature protein of 157 amino acids, which have no… Expand
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