Cloning of a mammalian DNA methyltransferase.

@article{Bestor1988CloningOA,
  title={Cloning of a mammalian DNA methyltransferase.},
  author={Timothy H Bestor},
  journal={Gene},
  year={1988},
  volume={74 1},
  pages={9-12}
}
Cloning and sequencing of cDNA clones has shown that mammalian DNA (cytosine-5)-methyltransferase comprises a 1000-amino acid (aa) N-terminal region of unknown function and a 570-aa C-terminal region that is clearly related to bacterial type-II cytosine restriction methyltransferases. These findings indicate that the mammalian enzyme contains at least two structural domains and suggest a common evolutionary origin for mammalian and prokaryotic DNA (cytosine-5)-methyltransferases. 

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Similar Papers

Loading similar papers…