Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases.

@article{Sagn1997CloningOA,
  title={Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases.},
  author={Corinne Sagn{\'e} and Salah El Mestikawy and M. F. Isambert and Maureen Hamon and J. P. Henry and Bruno Giros and Bruno Gasnier},
  journal={FEBS letters},
  year={1997},
  volume={417 2},
  pages={
          177-83
        }
}
The unc-47 locus of Caenorhabditis elegans has been suggested to encode a synaptic vesicle GABA transporter. Here we used hydropathy plot analysis to identify a candidate vesicular GABA transporter in genomic sequences derived from a region of the physical map comprising unc-47. A mouse homologue was identified and cloned from EST database information. In situ hybridization in rat brain revealed codistribution with both GABAergic and glycinergic neuronal markers. Moreover, expression in COS-7… CONTINUE READING

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