Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.

Abstract

Tumour-necrosis factor-alpha (TNF-alpha) is a cytokine that contributes to a variety of inflammatory disease states. The protein exists as a membrane-bound precursor of relative molecular mass 26K which can be processed by a TNF-alpha-converting enzyme (TACE), to generate secreted 17K mature TNF-alpha. We have purified TACE and cloned its complementary DNA… (More)

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@article{Moss1997CloningOA, title={Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.}, author={Michele Moss and S L Jin and Maria Milla and David M Bickett and William Burkhart and Harrison Carter and W. J. Chen and W. Clay and John Didsbury and Donald M. Hassler and Christina Hoffman and Th. Kost and Millard H. Lambert and M. Anthony Leesnitzer and Peter McCauley and Gerard M. McGeehan and J. Mitchell and Mark Moyer and Greg L Pahel and Warren J. Rocque and Larry Overton and Frank J. Schoenen and Theresa Seaton and J. L. Su and J. David Becherer}, journal={Nature}, year={1997}, volume={385 6618}, pages={733-6} }