Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation.

@article{Bhat1995CloningOA,
  title={Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation.},
  author={Pangala V. Bhat and J Labrecque and Jean Boutin and Andr{\'e} Lacroix and Akira Yoshida},
  journal={Gene},
  year={1995},
  volume={166 2},
  pages={303-6}
}
Retinoic acid (RA), an important regulator of cell differentiation, is biosynthesized from retinol via retinal by a two-step oxidation process. We previously reported the purification and partial amino acid (aa) sequence of a rat kidney aldehyde dehydrogenase (ALDH) isozyme that catalyzed the oxidation of 9-cis and all-trans retinal to corresponding RA with high efficiency [Labrecque et al. Biochem. J. 305 (1995) 681-684]. A rat kidney cDNA library was screened using a 291-bp PCR product… CONTINUE READING