Cloning of a Mycobacterium tuberculosis gene encoding a purifed protein derivative protein that elicits strong tuberculosis-specific delayed-type hypersensitivity.

@article{Coler2000CloningOA,
  title={Cloning of a Mycobacterium tuberculosis gene encoding a purifed protein derivative protein that elicits strong tuberculosis-specific delayed-type hypersensitivity.},
  author={Rhea N. Coler and Yasir A. W. Skeiky and Pamela J. Ovendale and Thomas S. Vedvick and L Gervassi and Jeffrey A. Guderian and S S Jen and Steven G Reed and Antonio Campos-Neto},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={182 1},
  pages={224-33}
}
The purified protein derivative (PPD) skin test has been used for the diagnosis of tuberculosis for more than 75 years. However, the test lacks specificity because all mycobacteria share antigens present in PPD. Therefore, sensitization with nontuberculous pathogenic or with environmental nonpathogenic mycobacteria can lead to positive skin tests. This communication describes a novel PPD protein present only in tuberculous complex mycobacteria. A recombinant protein was obtained and named DPPD… CONTINUE READING
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