Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon

@article{Still1999CloningOT,
  title={Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon},
  author={Ivan H. Still and Mark Hamilton and Pauline Vince and Alan Wolfman and John K Cowell},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={4032-4038}
}
Amplification of several chromosomal regions have been observed in human breast carcinomas. One such region, 8p11, is amplified in 10 – 15% of tumor samples. Although the FGFR1 gene is located close to this region, and is often included within the amplicon, the observation that tumors exhibiting 8p11 amplification do not always overexpress FGFR1 suggests that another gene located close to FGFR1 is involved in the tumorigenic process. We now report the precise location of four expressed sequence… CONTINUE READING
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