Cloning of P2XM, a novel human P2X receptor gene regulated by p53.

  title={Cloning of P2XM, a novel human P2X receptor gene regulated by p53.},
  author={Tomohiko Urano and Hiroyuki Nishimori and Haiyong Han and Tomohisa Furuhata and Yoriyoshi Kimura and Yusuke Nakamura and Takashi Tokino},
  journal={Cancer research},
  volume={57 15},
Through cloning of functional p53-binding sites (p53-tagged sites) from the human genome, we isolated a novel gene inducible by wild-type p53. Its cDNA sequence contained an open reading frame encoding a 431-amino acid peptide that showed a significant homology with members of the P2X family. This protein also revealed a similarity to RP-2, a gene activated in thymocytes undergoing programmed cell death. Northern blot analysis showed that it was expressed predominantly in skeletal muscle. Hence… CONTINUE READING
33 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 33 extracted citations

Similar Papers

Loading similar papers…