Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer

@article{Liu2018CloningOM,
  title={Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer},
  author={Zhen Liu and Yijun Cai and Yan Wang and Yanhong Nie and Qingnan Sun},
  journal={Cell},
  year={2018},
  volume={172},
  pages={881-887.e7}
}
Generation of genetically uniform non-human primates may help to establish animal models for primate biology and biomedical research. In this study, we have successfully cloned cynomolgus monkeys (Macaca fascicularis) by somatic cell nuclear transfer (SCNT). We found that injection of H3K9me3 demethylase Kdm4d mRNA and treatment with histone deacetylase inhibitor trichostatin A at one-cell stage following SCNT greatly improved blastocyst development and pregnancy rate of transplanted SCNT… CONTINUE READING

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Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer, Cell

  • Liu
  • https://doi.org/
  • 2018

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