Cloning of Human Preprotachykinin-I Promoter and the Role of Cyclic Adenosine 5′-Monophosphate Response Elements in Its Expression by IL-1 and Stem Cell Factor1 2

@article{Qian2001CloningOH,
  title={Cloning of Human Preprotachykinin-I Promoter and the Role of Cyclic Adenosine 5′-Monophosphate Response Elements in Its Expression by IL-1 and Stem Cell Factor1 2},
  author={Jing Qian and Ghassan Yehia and Claudia Molina and Annemarie Fernandes and Robert J Donnelly and Devashish J. Anjaria and Pedro Gasc{\'o}n and Pranela Rameshwar},
  journal={The Journal of Immunology},
  year={2001},
  volume={166},
  pages={2553 - 2561}
}
Preprotachykinin-I gene (PPT-I) encodes several peptides with organ-specific functions that link the neuroendocrine-immune-hemopoietic axis. We cloned upstream of the initiation site of human PPT-I promoter and identified consensus sequences for two cAMP response elements (CRE). PPT-I is induced by cytokines including those that signal through the cAMP pathway. Therefore, we studied the role of the two CRE in IL-1α and stem cell factor (SCF) stimulation of bone marrow stroma because both… Expand
Regulation of the preprotachykinin‐I gene promoter through a protein kinase A‐dependent, cyclic AMP response element‐binding protein‐independent mechanism
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