Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

  title={Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.},
  author={Chris Kingsley and Astar Winoto},
  journal={Molecular and cellular biology},
  volume={12 10},
Analysis of a T-cell antigen receptor (TCR) alpha promoter from a variable gene segment (V) revealed a critical GT box element which is also found in upstream regions of several V alpha genes, TCR enhancer, and regulatory elements of other genes. This element is necessary for TCR gene expression and binds several proteins. These GT box-binding proteins were identified as members of a novel Sp1 multigene family. Two of them, which we term Sp2 and Sp3, were cloned. Sp2 and Sp3 contain zinc… CONTINUE READING
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