Cloning of B cell‐specific membrane tetraspanning molecule BTS possessing B cell proliferation‐inhibitory function

@article{Suenaga2007CloningOB,
  title={Cloning of B cell‐specific membrane tetraspanning molecule BTS possessing B cell proliferation‐inhibitory function},
  author={Tadahiro Suenaga and Hisashi Arase and Sho Yamasaki and Masayuki Kohno and Tadashi Yokosuka and Arata Takeuchi and Takamichi Hattori and Takashi Saito},
  journal={European Journal of Immunology},
  year={2007},
  volume={37}
}
Lymphocyte proliferation is regulated by signals through antigen receptors, co‐stimulatory receptors, and other positive and negative modulators. Several membrane tetraspanning molecules are also involved in the regulation of lymphocyte growth and death. We cloned a new B cell‐specific tetraspanning (BTS) membrane molecule, which is similar to CD20 in terms of expression, structure and function. BTS is specifically expressed in the B cell line and its expression is increased after the pre‐B… Expand
Characterisation of the voltage gated proton channel HVCN1 in B cells
HVCN1 is a voltage-gated proton channel, detected in a proteomic screen profiling membrane proteins of Mantle Cell Lymphoma cells. Subsequent analysis showed that HVCN1 is expressed in naive matureExpand
Molecular and Functional Characterization of Hv1 Proton Channel in Human Granulocytes
TLDR
Results of subcellular fractionation and confocal imaging indicate that Hv1 is resident in both plasmalemmal and granular membrane compartments of resting neutrophils and it is demonstrated that a massive reduction in HV1 expression can limit the Nox2 mediated superoxide production of PLB-985 granulocytes. Expand
Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses
TLDR
It is demonstrated that myelin-associated glycoprotein (MAG), mainly distributed in neural tissues, associates with VZV glycop protein B (gB) and promotes cell-cell fusion when coexpressed with VzV gB and gH/gL. Expand
Physiological roles of voltage‐gated proton channels in leukocytes
TLDR
Proton channels are multitalented channels that control male fertility as well as the authors' innate and adaptive immunity, and mediates the intracellular alkalinisation required for the activation of spermatozoids. Expand
Voltage-gated proton channel is expressed on phagosomes.
TLDR
Superoxide anion production upon PMA activation was significantly reduced in neutrophils from VSOP/Hv1 knockout mice, consistent with the idea that voltage-gated proton channels help NADPH oxidase in phagocytes to produce reactive oxygen species. Expand
Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology.
TLDR
V1 functions independently of NOX: for example in snail neurons, basophils, osteoclasts, and cancer cells, and strong evidence for a role of HV1 is also emerging in sperm biology, but the relationship with the sperm NOX5 remains unclear. Expand
Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology
TLDR
Strong evidence for a role of HV1 is also emerging in sperm biology, but the relationship with the sperm N... Expand
Proton pump inhibitors have pH-dependent effects on the thermostability of the carboxyl-terminal domain of voltage-gated proton channel Hv1
TLDR
The preferential interaction of PPIs with the inactive form of Hv1 stabilizes the high pH inactive state of the C-terminal domain, indicating a mechanism by which PPIs might act explicitly on the stabilization of a closed state ofThe proton channel. Expand
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst
TLDR
It is shown that Hv1 expression is required for measurable voltage-gated H+ current in unstimulated phagocytes, suggesting that HV1 contributes a majority of the charge compensation required for optimal NADPH oxidase activity. Expand
Zinc modulation of proton currents in a new voltage‐gated proton channel suggests a mechanism of inhibition
TLDR
The effects of Zn2+ and Cd2+ on HV1 from Nicoletia phytophila confirm that NpHV1 functions as a dimer and support the hypothesis that zinc is coordinated in between the dimer instead of the monomer. Expand
...
1
2
...

References

SHOWING 1-10 OF 54 REFERENCES
Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes
TLDR
The findings that the earliest activation events and phorbol myristate acetate‐induced proliferation were not inhibited by antibody binding to B1 suggest that inhibition is due to the blocking of a step of the activation process required for cell cycle progression and differentiation, rather than blocking initial signal transduction across the membrane or providing a negative or suppressive signal. Expand
Regulation of human B-cell activation and adhesion.
TLDR
Understanding how B cell accessory molecules regulate key interconnections during development may provide insights into the control and management of diseases with B-cell dysfunctions. Expand
CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
TLDR
CD81 (TAPA-1) is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses and is reported to influence adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells. Expand
NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.
TLDR
The results suggest that NFAM1 modulates B cell signaling through its ITAM, which regulates B cell development. Expand
Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies.
TLDR
It is suggested that ligation of CD20 in vivo by anti-CD20 antibodies in the presence of FcR-expressing cells may initiate signal transduction events that induce elevation of [Ca2+]i and lead to apoptosis of malignant B cells, thereby contributing to the impressive tumor regressions observed in mouse models and clinical trials using anti- CD20 MoAbs. Expand
Targeted Inactivation of the Tetraspanin CD37 Impairs T-Cell-Dependent B-Cell Response under Suboptimal Costimulatory Conditions
TLDR
A role for CD37 in T-cell–B-cell interactions which manifests itself under suboptimal costimulatory conditions is suggested. Expand
BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation.
TLDR
Results show that alpha 4 plays a pivotal role in antigen-specific signal transduction during B cell activation and differentiation in vivo. Expand
Human HTm4 is a hematopoietic cell cycle regulator.
Proper control of cell cycle progression is critical for the constant self-renewal, differentiation, and homeostasis of the hematopoietic system. Cells of all types share the common cell cycleExpand
Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment.
TLDR
Verification of the location of both the intracellular and extracellular regions of the CD20 molecule is provided and a membrane-proximal sequence in the cytoplasmic carboxyl tail that is required for CD20 to redistribute to detergent-insoluble membrane microdomains is identified. Expand
Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes
TLDR
Findings indicate that CD20 directly regulates transmembrane Ca2+ conductance in B lymphocytes, and suggest that multimeric complexes of CD20 may form Ca2- conductive ion channels in the plasma membrane of B lymphoid cells. Expand
...
1
2
3
4
5
...