Cloning for conservation

  title={Cloning for conservation},
  author={Andrew Marshall},
  journal={Nature Biotechnology},
  • A. Marshall
  • Published 1 November 2000
  • Biology
  • Nature Biotechnology
Researchers have published the first systematic analysis of the effects of various inducing factors on embryonic stem (ES) cell differentiation (PNAS 97, 11307–11312, 2000). The work represents an important step toward efforts to direct ES cell differentiation toward specific cell types (e.g., insulin-producing pancreatic β-cells) for cell replacement therapies. To achieve their aim, Douglas Melton and his colleagues first tested ES cells for the expression of eight inducing factor receptors to… 

Development of interspecies cloned monkey embryos reconstructed with bovine enucleated oocytes.

It is suggested that bovine ooplasm could support dedifferentiation of monkey somatic cell nuclei but could not support embryo development to either the compact morula or blastocyst stage.

Interspecies Implantation and Mitochondria Fate of Panda-Rabbit Cloned Embryos1

It is demonstrated that panda-rabbit cloned embryos can implant in the uterus of a third species, the domestic cat, and mitochondrial-specific probes of panda and rabbit reveal that mitochondria from donor cells may substitute those from recipient oocytes in postimplanted, interspeciesCloned embryos.

In vitro maturation of oocytes derived from the brown bear (Ursus arctos).

Results indicate that bear oocytes can develop to metaphase II in an in vitro culture system and that activated oocytes that developed to the 2 or 4-cell stage was 31.6%; however, no blastocysts were observed.