Cloning and structural analysis of IgM (mu chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica.

@article{Aveskogh1999CloningAS,
  title={Cloning and structural analysis of IgM (mu chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica.},
  author={Maria Aveskogh and Lars Pilstr{\"o}m and Lars Hellman},
  journal={Developmental and comparative immunology},
  year={1999},
  volume={23 7-8},
  pages={597-606}
}
To address the question of the Ig isotype repertoire of non placental mammals, we have examined the Ig expression in the marsupial Monodelphis domestica (grey short tailed opossum). Screening of an opossum spleen cDNA library has previously led to the isolation of full length clones for opossum IgG (gamma chain), IgE (epsilon chain) and IgA (alpha chain). We now present the isolation of several cDNA clones encoding the entire constant regions of the opossum IgM (mu chain). A comparative… CONTINUE READING
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