Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.

@article{Nicosia1986CloningAS,
  title={Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.},
  author={Alfredo Nicosia and Mary Perugini and Carlo Franzini and M. C. Casagli and Marco Borri and Giani D. Antoni and M Almoni and Paolo Neri and Giulio Ratti and Rino Rappuoli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 13},
  pages={4631-5}
}
Pertussis toxin, a protein composed of five different subunits (S1, S2, S3, S4, and S5), is the major virulence factor of Bordetella pertussis. We have cloned and sequenced a DNA fragment of 4.7 kilobases that contains the genes coding for the five subunits. The genes are clustered within 3.2 kilobases in the following order: S1, S2, S4, S5, and S3. A sequence closely resembling Escherichia coli promoters is found only before the S1 gene, and a possible termination signal is present at the end… CONTINUE READING
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