Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

@article{Goedert1989CloningAS,
  title={Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.},
  author={Michel Goedert and Maria Grazia Spillantini and Marie-Claude Potier and J{\"u}rg Ulrich and R. A. Crowther},
  journal={The EMBO journal},
  year={1989},
  volume={8 2},
  pages={393-9}
}
We have isolated cDNA clones encoding a 383-amino acid isoform of the human microtubule-associated protein tau. It differs from previously determined tau sequences by the presence of an additional repeat of 31 amino acids, giving four, rather than three, tandem repeats in its carboxy-terminal half. The extra repeat is encoded by a separate exon. Probes derived from cDNA clones encoding the three (type I) and four repeat (type II) tau protein isoforms detected mRNAs for both forms in all adult… CONTINUE READING
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