Cloning and sequence analysis of the human brain β‐adrenergic receptor

  title={Cloning and sequence analysis of the human brain $\beta$‐adrenergic receptor},
  author={F. Chung and K. Lentes and J. Gocayne and M. FitzGerald and D. Robinson and A. Kerlavage and C. Fraser and J. Venter},
  journal={FEBS Letters},
Two cDNA clones, λ‐CLFV‐108 and λ‐CLFV‐119, encoding for the β‐adrenergic receptor, have been isolated from a human brain stem cDNA library. One human genomic clone, LCV‐517 (20 kb), was characterized by restriction mapping and partial sequencing. The human brain β‐receptor consists of 413 amino acids with a calculated M r of 46 480. The gene contains three potential glucocorticoid receptor‐binding sites. The β‐receptor expressed in human brain was homology with rodent (88%) and avian (52… Expand


Interaction of the Glucocorticoid Receptor with Specific DNA Sequences (Litwack, G. ed
  • Biochemical Actions of Hormones,
  • 1986
Membranes, Detergents and Receptor Solubilization (Venter, J.C
  • 1984
Monoclonal and Anti
  • 1984
Monoclonal and AntiIdiotypic Antibodies. Probes for Receptor Structure and Function (Venter
  • J.C. et al. eds) Receptor Biochemistry and Methodology,
  • 1984
in : Monoclonal and Anti - Idiotypic Antibodies
  • Probes for Receptor Structure and Function
  • 1984