Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II.

@article{Schn2006CloningAR,
  title={Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II.},
  author={Sylvia Sch{\"o}n and Christian Prante and Claudia Bahr and Joachim Kuhn and Knut Kleesiek and Christian G{\"o}tting},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 20},
  pages={14224-31}
}
Xylosyltransferase I (XT-I) catalyzes the transfer of xylose from UDP-xylose to serine residues in proteoglycan core proteins. This is the first and apparently rate-limiting step in the biosynthesis of the tetrasaccharide linkage region in glycosaminoglycan-containing proteoglycans. The XYLT-II gene codes for a highly homologous protein, but its physiological function is not yet known. Here we present for the first time the construction of a vector encoding the full-length GFP-tagged human XT-I… CONTINUE READING

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