Cloning and physical mapping of the HLA class I region spanning the HLA-E-to-HLA-F interval by using yeast artificial chromosomes.

@article{Geraghty1992CloningAP,
  title={Cloning and physical mapping of the HLA class I region spanning the HLA-E-to-HLA-F interval by using yeast artificial chromosomes.},
  author={Daniel E. Geraghty and Jimin Pei and Benjamin A. Lipsky and John A Hansen and Patricia Taillon-Miller and Sarah K. Bronson and David D. Chaplin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 7},
  pages={2669-73}
}
The HLA class I genes are located within a 2-million-base pair (2-Mbp) region constituting the telomeric half of the human major histocompatibility complex. The large majority of the class I sequences, including the HLA-A, -E, -F, and -G genes, is found within the telomeric 1 Mbp. We report here the isolation and characterization of yeast artificial chromosome (YAC) clones that span a contiguous region of greater than 1.2 Mbp and include 14 of the 18 characterized class I sequences. Restriction… CONTINUE READING
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