Cloning and pharmacological characterization of a rat kappa opioid receptor.

@article{Meng1993CloningAP,
  title={Cloning and pharmacological characterization of a rat kappa opioid receptor.},
  author={Fan Meng and Guo Xiu Xie and Robert A. Thompson and Alfred Mansour and Avram Goldstein and Stanley J. Watson and Huda Akil},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 21},
  pages={9954-8}
}
A full-length cDNA was isolated from a rat striatal library by using low-stringency screening with two PCR fragments, one spanning transmembrane domains 3-6 of the mouse delta opioid receptor and the other unidentified but homologous to the mouse delta receptor from rat brain. The novel cDNA had a long open reading frame encoding a protein of 380 residues with 59% identity to the mouse delta receptor and topography consistent with a seven-helix guanine nucleotide-binding protein-coupled… CONTINUE READING
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