Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene.

@article{Davies1997CloningAM,
  title={Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene.},
  author={Joanna P. Davies and Philip D. Cotter and Yiannis A. Ioannou},
  journal={Genomics},
  year={1997},
  volume={41 1},
  pages={131-4}
}
Rab GTPases reside in specific intracellular compartments and are key regulators of vesicular transport. To facilitate studies of the mechanism of lysosomal integral membrane protein (LAMP-1) transport, cDNAs for human Rab7 and Rab9 were isolated, and their nucleotide sequences were determined. During isolation and characterization of these cDNAs a Rab9 pseudogene was identified. The sequences are highly homologous to other mammalian Rab proteins and also share homology with proteins of the Rab… CONTINUE READING

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