Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain.

@article{Monteggia2000CloningAL,
  title={Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain.},
  author={Lisa M. Monteggia and Amelia J Eisch and M D Tang and Leonard K Kaczmarek and Eric J. Nestler},
  journal={Brain research. Molecular brain research},
  year={2000},
  volume={81 1-2},
  pages={
          129-39
        }
}
Rhythmic firing in brain and heart is mediated by pacemaker channels that are activated by hyperpolarization and regulated directly by cyclic nucleotides. Recent work has identified a new gene family that encodes such channels, which are termed hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels. In this study, we report the molecular cloning and localization by in situ hybridization of HCN1-4 in adult rat brain. The rat HCN1-4 clones show high homology to the deduced amino acid… CONTINUE READING

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