Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

@article{Sharp1993CloningAG,
  title={Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia},
  author={Daru Young Sharp and Laura Blinderman and Kelly A. Combs and Bernadette K. Kienzle and Beverly Ricci and Karen Wager-Smith and Cleris M. Gil and Christoph W. Turck and Marie-Elizabeth Boumas and Daniel J. Rader and Lawrence P. Aggerbeck and Richard E. Gregg and David A. Gordon and John Rowley Wetterau},
  journal={Nature},
  year={1993},
  volume={365},
  pages={65-69}
}
THE microsomal triglyceride transfer protein (MTP), which catalyses the transport of triglyceride, cholesteryl ester and phospho-lipid between phospholipid surfaces, is a heterodimer composed of the multifunctional protein, protein disulphide isomerase, and a unique large subunit with an apparent Mr of 88K (refs 1–3). It is isolated as a soluble protein from the lumen of the microsomal fraction of liver and intestine4. The large subunit of MTP was not detectable in four unrelated subjects with… CONTINUE READING
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