Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).

@article{Kekuda1996CloningAF,
  title={Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).},
  author={Ramesh Kekuda and Puttur D Prasad and You-jun Fei and Frederick H. Leibach and Vadivel Ganapathy},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={229 2},
  pages={553-8}
}
We have isolated a cDNA clone from a human placental choriocarcinoma cell (JAR) cDNA library which codes for a functional type 1 sigma receptor. An RT-PCR product obtained from guinea pig kidney mRNA using primers specific for the guinea pig sigma receptor cDNA was used to screen the cDNA library. The hSigmaR1 cDNA predicts a protein of 223 amino acids with a single putative transmembrane domain. The amino acid sequence exhibits 93% identity with the guinea pig sigma receptor. When functionally… CONTINUE READING
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