Cloning and functional expression of the human histamine H3 receptor.

  title={Cloning and functional expression of the human histamine H3 receptor.},
  author={Timothy W. Lovenberg and Barbara L Roland and Sandy J Wilson and Xiaoxia Jiang and Jagdeesh Pyati and Arne Huvar and Michael R. Jackson and Mark G. Erlander},
  journal={Molecular pharmacology},
  volume={55 6},
Histamine regulates neurotransmitter release in the central and peripheral nervous systems through H3 presynaptic receptors. The existence of the histamine H3 receptor was demonstrated pharmacologically 15 years ago, yet despite intensive efforts, its molecular identity has remained elusive. As part of a directed effort to discover novel G protein-coupled receptors through homology searching of expressed sequence tag databases, we identified a partial clone (GPCR97) that had significant… CONTINUE READING
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