Cloning and functional expression of a human liver organic cation transporter.

@article{Zhang1997CloningAF,
  title={Cloning and functional expression of a human liver organic cation transporter.},
  author={Lelin Zhang and Mark J. Dresser and Andrew T. Gray and S C Yost and Shinichi Terashita and Kathleen M. Giacomini},
  journal={Molecular pharmacology},
  year={1997},
  volume={51 6},
  pages={
          913-21
        }
}
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and xenobiotics. In contrast to our understanding of the mechanisms of organic cation transport in rat liver, little is known about the mechanisms of organic cation transport in the human liver. We report the cloning, sequencing, and functional characterization of the first human polyspecific organic cation transporter from liver (hOCT1). hOCT1 (554 amino acids) is 78% identical to… CONTINUE READING
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