Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate.

@article{Prasad1998CloningAF,
  title={Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate.},
  author={Puttur D Prasad and Hong Wang and Ramesh Kekuda and Takashi Fujita and You-jun Fei and Lawrence D. Devoe and Frederick H. Leibach and Vadivel Ganapathy},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 13},
  pages={7501-6}
}
Previous studies have shown that a Na+-dependent transport system is responsible for the transplacental transfer of the vitamins pantothenate and biotin and the essential metabolite lipoate. We now report the isolation of a rat placental cDNA encoding a transport protein responsible for this function. The cloned cDNA, when expressed in HeLa cells, induces Na+-dependent pantothenate and biotin transport activities. The transporter is specific for pantothenate, biotin, and lipoate. The Michaelis… CONTINUE READING
42 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

References

Publications referenced by this paper.

Cloning of a Na1-dependent Vitamin Transporter

  • D. S. Vallari, C. O. Rock
  • J. Bacteriol
  • 1985
1 Excerpt

Similar Papers

Loading similar papers…