Cloning and functional characterization of the HRASLS2 gene

  title={Cloning and functional characterization of the HRASLS2 gene},
  author={R.-Y. Shyu and Y.-C. Hsieh and F.-M. Tsai and C.-C. Wu and S.-Y. Jiang},
  journal={Amino Acids},
The HRAS-like suppressor 2 (HRASLS2) gene belongs to the H-REV107 gene family involved in the regulation of cell growth and differentiation. HRASLS2 is expressed at high levels in normal tissues of the small intestine, kidney, and trachea. We cloned HRASLS2 cDNA from human SW480 colon cancer cells. Most wild-type, and some N- and C-terminal truncated HRASLS2 (HRASLS2ΔNΔC) were expressed as a granular pattern located at perinuclear region in HtTA cervical cancer cells, while truncation at the C… CONTINUE READING
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