Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain.

@article{Andriamampandry2007CloningAF,
  title={Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain.},
  author={Christian Andriamampandry and Omar Taleb and V{\'e}ronique Kemmel and Jean-Paul Humbert and Dominique Aunis and Michel Maitre},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 3},
  pages={
          885-95
        }
}
Two parent clones of a gamma-hydroxybutyrate (GHB) receptor, C12K32 and GHBh1, were isolated from a human frontal cortex cDNA library. The two clones differ by a deleted cytosine in C12K32. CHO cells transfected with either C12K32 or GHBh1 responded positively to submicromolar GHB stimulation. However, unlike C12K32, GHBh1 desensitizes rapidly on application of low concentrations of GHB. GHB receptor properties were then studied on C12K32 expressed in CHO cells. C12K32 bound GHB with a Kd of… CONTINUE READING

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