Cloning and functional characterisation of the human TRH receptor

  title={Cloning and functional characterisation of the human TRH receptor},
  author={Sarah M. Duthie and Patricia L Taylor and Lucy Anderson and Jesse Cook and Karin Ann Eidne},
  journal={Molecular and Cellular Endocrinology},
Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide known to act via its receptor in the anterior pituitary gland to stimulate the release of thyrotrophin (TSH) from thyrotrophs and prolactin (PRL) from lactotrophs. It is also thought to act as a neurotransmitter/neuromodulator in the central and peripheral nervous systems. We have isolated a cDNA encoding the human pituitary TRH receptor (TRH-R) protein with a predicted amino acid sequence of 398 amino acids. Comparison of the… CONTINUE READING


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