Cloning and functional analysis of the mouse c-kit promoter.

  title={Cloning and functional analysis of the mouse c-kit promoter.},
  author={Hideyo Yasuda and Stephen J. Galli and E. N. Geissler},
  journal={Biochemical and biophysical research communications},
  volume={191 3},
The c-kit protooncogene encodes a tyrosine kinase receptor expressed during ontogeny and adult life by several important and developmentally distinct cell lineages. Mice carrying germ line c-kit mutations exhibit deficiencies in most of these lineages, demonstrating that c-kit function is necessary for their normal development. To facilitate the identification of cis-acting elements which regulate tissue-specific c-kit expression, we cloned and characterized a mouse c-kit promoter which is… CONTINUE READING
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