Cloning and functional analysis of a polymorphic variant of the ovine Mel 1a melatonin receptor.

@article{Barrett1997CloningAF,
  title={Cloning and functional analysis of a polymorphic variant of the ovine Mel 1a melatonin receptor.},
  author={Perry Barrett and Shaun Conway and Ralf Jockers and Arthur Donny Strosberg and B{\'e}atrice Guardiola-Lema{\^i}tre and Philippe Delagrange and P Jeffrey Morgan},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1356 3},
  pages={
          299-307
        }
}
We have isolated a novel variant of the Mel 1a melatonin receptor from an ovine PT cDNA library. Relative to the reported sequence for the Mel 1a melatonin receptor there are 8 changes in the DNA sequence. Only 3 of these result in amino acid substitutions, one in extracellular loop 3 and two in the carboxy-terminal tail. We have designated the novel variant of the sheep Mel 1a receptor Mel 1a(beta), and correspondingly the previously reported variant Mel 1a(alpha). As minor changes in the… CONTINUE READING
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