Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

@article{Bonner1988CloningAE,
  title={Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes},
  author={T. Bonner and Alice C. Young and Mark R. Bran and N. Buckley},
  journal={Neuron},
  year={1988},
  volume={1},
  pages={403-410}
}
The human and rat genes for a fifth muscarinic receptor have been cloned and expressed in mammalian cells. The 532 amino acid human protein has 89% sequence identity to the 531 amino acid rat protein and is most closely related to the m3 receptor. Both proteins are encoded by single exons. The receptor has intermediate affinity for pirenzepine and low affinity for AF-DX 116, and it increases metabolism of phosphatidylinositol when stimulated with carbachol. Expression of mRNA has yet to be… Expand
701 Citations
The molecular basis of muscarinic receptor diversity
  • T. Bonner
  • Biology, Medicine
  • Trends in Neurosciences
  • 1989
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