Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

@article{Lok1994CloningAE,
  title={Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo},
  author={Si Chong Laurence Lok and Kenneth Kaushansky and Richard D. Holly and Joseph L. Kuijper and Catherine E. Lofton-Day and Pieter J. Oort and F. J. Grant and Mark D. Heipel and Steve K. Burkhead and Janet M. Kramer and Linda A. Bell and Cindy A. Sprecher and Hal Blumberg and Rebecca Johnson and Donna E. Prunkard and Andrew T. Ching and Shannon L. Mathewes and Mason C. Bailey and John W. Forstrom and Michele M. Buddle and Sherri G. Osborn and Simon J. Evans and Paul O. Sheppard and Scott R. Presnell and P. J. O'Hara and Fredrick S. Hagen and Gerald J. Roth and Donald C. Foster},
  journal={Nature},
  year={1994},
  volume={369},
  pages={565-568}
}
THE major regulator of circulating platelet levels is believed to be a cytokine termed thrombopoietin1,2. It is thought to be a lineage-specific cytokine affecting the proliferation and maturation of committed cells resulting in the production of megakaryocytes and platelets. Despite considerable efforts by a number of laboratories, the unequivocal identification of thrombopoietin has proven elusive. Here we report the functional cloning of a murine complementary DNA encoding a ligand for the… CONTINUE READING

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