Cloning and expression of murine SC1, a gene product homologous to SPARC.

@article{Soderling1997CloningAE,
  title={Cloning and expression of murine SC1, a gene product homologous to SPARC.},
  author={Jacquelyn A. Soderling and May J Reed and Amoreena C. Corsa and Elizabeth Sage},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1997},
  volume={45 6},
  pages={823-35}
}
A number of cDNAs (SC1, QR1, and hevin) have been shown to be similar to SPARC (secreted protein acidic and rich in cysteine), a matricellular protein that regulates cell adhesion, cell cycle, and matrix assembly and remodeling. These proteins are 61-65% identical in the final 200 residues of their C-termini; their N-terminal sequences are related but more divergent. All have an overall acidic pl, with a follistatin-like region that is rich in cysteine, and a Ca+2 binding consensus sequence at… CONTINUE READING