Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system.

@article{Houtani2005CloningAE,
  title={Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system.},
  author={Takeshi Houtani and Yumi Munemoto and Masahiko Kase and Satoru Sakuma and Toshiyuki Tsutsumi and Tetsuo Sugimoto},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={335 2},
  pages={
          277-85
        }
}
An orphan receptor of ligand-gated ion-channel type (L2, also termed ZAC according to the presence of zinc ion for channel activation) was identified by computer-assisted search programs on human genome database. The L2 protein shares partial homology with serotonin receptors 5HT3A and 5HT3B. We have cloned L2 cDNA derived from human caudate nucleus and characterized the exon-intron structure as follows: (1) The L2 protein has four transmembrane regions (M1-M4) and a long cytoplasmic loop… CONTINUE READING

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