Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.

  title={Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.},
  author={K. A. Comer and Josie L. Falany and Charles N. Falany},
  journal={The Biochemical journal},
  volume={289 ( Pt 1)},
Dehydroepiandrosterone sulphotransferase (DHEA-ST) catalyses the 3'-phosphoadenosine 5'-phosphosulphate-dependent sulphation of a wide variety of steroids in human liver and adrenal tissue and is responsible for most, if not all, of the sulphation of bile acids in human liver. This report describes the isolation, characterization and expression of a cDNA which encodes human liver DHEA-ST. The DHEA-ST cDNA, designated DHEA-ST8, was isolated from a Uni-Zap XR human liver cDNA library and is… CONTINUE READING