Cloning and expression of human and rat Dt dopamine receptors

@article{Zhou1990CloningAE,
  title={Cloning and expression of human and rat Dt dopamine receptors},
  author={Qun Zhou and David K. Grandy and Lisa Thambi and Jake A. Kushner and Hubert H.M. Van Tol and Roger D. Cone and David Pribnow and John A. Salon and James R. Bunzow and Olivier Civelli},
  journal={Nature},
  year={1990},
  volume={347},
  pages={76-80}
}
THE importance of the dopaminergic system in brain function has been emphasized by its association with neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. On the basis of their biochemical and pharmacological characteristics, dopamine receptors are classified into D1 and D2 subtypes1,2. As the most abundant dopamine receptor in the central nervous system, D1 receptors seem to mediate some behavioural responses3, modulate activity of D2 dopamine receptors4,5… 

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

The cloning of a gene encoding a 477-amino-acid protein with strong homology to the cloned Dt receptor is reported here the existence of a dopamine D1-like receptor with these characteristics had not been predicted and may represent an alternative pathway for dopamine-mediated events and regulation of D2 receptor activity.

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine.

Expression of the dopamine D2 receptor gene in brain

Brain Dopamine Receptors: A Primer on Their Current Status, Basic and Clinical

The discovery and definition of new gene products now require long‐term efforts to clarify their physiology and to develop a pharmacology of novel dopamine receptors and their effectors.

Subtypes and localization of dopamine receptors in human brain

  • J. Keyser
  • Biology, Psychology
    Neurochemistry International
  • 1993

The Dopamine D1 Receptors

Dopaminergic receptors are members of a large gene family of hormone/neurotransmitter receptors that exert their biological actions via signal transduction pathways that involve guanine nucleotide-binding proteins.

The dopamine D(4) receptor: one decade of research.

Dopamine receptors and brain function

...

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