Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters.

@article{Guo1996CloningAE,
  title={Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters.},
  author={Weinong Guo and Mia C. Nichol and John Paul Merlie},
  journal={FEBS letters},
  year={1996},
  volume={398 2-3},
  pages={259-64}
}
We have cloned and sequenced mouse utrophin cDNA, and successfully expressed full length utrophin (400 kDa) in both muscle and non-muscle cells. The expression of recombinant utrophin is compared with that of its homologue, dystrophin (427 kDa). We demonstrate that recombinant utrophin is targeted into agrin-induced acetylcholine receptor (AChR) clusters, while recombinant dystrophin is evenly distributed along cell membranes in cultured Sol 8 muscle cells. This observation suggests that… CONTINUE READING
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