Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.

@article{Kao1994CloningAE,
  title={Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.},
  author={Peter N Kao and Lijie Chen and Gerald Brock and Jingjing Ng and John Kenny and Anne K. Smith and Blaise Corth{\'e}sy},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 32},
  pages={20691-9}
}
Nuclear Factor of Activated T-cells (NF-AT) is a crucial transcription factor required for T-cell expression of interleukin 2. Purified NF-AT contains 45-kDa and 90-kDa subunits (Corthésy, B., and Kao, P. N. (1994) J. Biol. Chem. 269, 20682-20690). Partial internal amino acid sequences derived from each subunit indicate that these proteins are novel. The amino acid sequences were used to clone the cDNAs encoding each subunit. The cDNAs predict proteins of novel structures: NF45 has limited… CONTINUE READING

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