Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

@article{Romkes1991CloningAE,
  title={Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.},
  author={M Romkes and Michael B. Faletto and Joyce A. Blaisdell and Judy L. Raucy and Joyce A. Goldstein},
  journal={Biochemistry},
  year={1991},
  volume={30 13},
  pages={3247-55}
}
The present study characterizes the profile of cDNAs from the human P450IIC subfamily in a library from one individual, and it describes three new members of this subfamily (IIC17, IIC18, and IIC19) isolated from two human cDNA libraries. cDNA libraries were constructed from two human livers which differed phenotypically in the hepatic content of P450 HLx (IIC8). The library from the phenotypically low HLx individual was screened by using a cDNA for rat liver P450IIC13 and an oligonucleotide… CONTINUE READING

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