Cloning and expression of cDNA for a human thromboxane A2 receptor

  title={Cloning and expression of cDNA for a human thromboxane A2 receptor},
  author={M. Hirata and Y. Hayashi and F. Ushikubi and Y. Yokota and R. Kageyama and S. Nakanishi and S. Narumiya},
  • M. Hirata, Y. Hayashi, +4 authors S. Narumiya
  • Published 1991
  • Biology, Medicine
  • Nature
  • THROMBOXANE A2 is a very unstable arachidonate metabolite, yet a potent stimulator of platelet aggregation and a constrictor of vascular and respiratory smooth muscles1. It has been implicated as a mediator in diseases such as myocardial infarction, stroke and bronchial asthma2. Using a stable analogue of this compound we recently purified the human platelet thromboxane A2 receptor to apparent homogeneity3. Using an oligonucleotide probe corresponding to its partial amino-acid sequence, we have… CONTINUE READING
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