Cloning and expression of a rat D2 dopamine receptor cDNA

  title={Cloning and expression of a rat D2 dopamine receptor cDNA},
  author={James R. Bunzow and Hubert H. M. Van Tol and David K. Grandy and Paul R. Albert and John A. Salon and Macdonald J. Christie and Curtis A. Machida and Kim A. Neve and Olivier Civelli},
Dopamine receptors are classified into D1 and D2 subtypes on the basis of their pharmacological and biochemical characteristics1,2. The D2 dopamine receptor has been implicated in the pathophysiology and treatment of movement disorders3, schizophrenia4 and drug addiction5. The D2 dopamine receptor interacts with guanine nucleotide-binding proteins to induce second messenger systems6,7. Other members of the family of receptors that are coupled to G proteins share a significant similarity in… 

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Human dopamine D1 receptor encoded by an intronless gene on chromosome 5

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The discovery of the dopamine D4 receptor stems from the same principle as the one which led to the cloning of the D2 and the other dopamine receptors: the recognition that G protein-coupled

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An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

A DNA fragment in the human genome is cloned and sequenced which cross-hybridizes with a full-length β2-adrenergic receptor probe at reduced stringency and appears to be intronless, containing an uninterrupted long open reading frame which encodes a putative protein with all the expected structural features of a G-protein-coupled receptor.

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

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Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.

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cDNA eloping of bovine substance-K receptor through oocyte expression system

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Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

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