Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R.

@article{Huang2005CloningAE,
  title={Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R.},
  author={Jia Huang and Xian-hua Chen and Kun Wu and Ping Xu},
  journal={Neuroreport},
  year={2005},
  volume={16 7},
  pages={
          727-30
        }
}
In the present study, we cloned a novel isoform of heterogeneous nuclear ribonucleoprotein-R (hnRNP-R), hnRNP-R2. Compared with the previously reported hnRNP-R (hnRNP-R1), it lacks the exon 5. Two proteins are both nuclear. The expression of hnRNP-R1 is not tissue-specific and is strikingly higher than that of hnRNR-R2. In comparison, the expression of hnRNP-R2 is low and neural-specific. The expression of two isoforms is differentially regulated during brain development. The results suggest… CONTINUE READING
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