Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms.

@article{Lundberg2001CloningAE,
  title={Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms.},
  author={Mathias Lundberg and Catrine Johansson and Joya Chandra and Mari Enoksson and Gunilla Jacobsson and Johanna Ljung and Magnus Johansson and Arne Holmgren},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 28},
  pages={26269-75}
}
Glutaredoxin (Grx) is a glutathione-dependent hydrogen donor for ribonucleotide reductase. Today glutaredoxins are known as a multifunctional family of GSH-disulfide-oxidoreductases belonging to the thioredoxin fold superfamily. In contrast to Escherichia coli and yeast, a single human glutaredoxin is known. We have identified and cloned a novel 18-kDa human dithiol glutaredoxin, named glutaredoxin-2 (Grx2), which is 34% identical to the previously known cytosolic 12-kDa human Grx1. The human… CONTINUE READING
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Cloning of a Novel Human Glutaredoxin

  • B. Rost, C. Sander
  • J. Mol. Biol
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