Cloning and expression of a human ATP-citrate lyase cDNA.

  title={Cloning and expression of a human ATP-citrate lyase cDNA.},
  author={Nabil A. Elshourbagy and J C Near and P J Kmetz and Timothy N. C. Wells and Pieter H. E. Groot and B A Saxty and Sara A. Hughes and Margaret Franklin and Israel S. Gloger},
  journal={European journal of biochemistry},
  volume={204 2},
A full-length cDNA clone of 4.3 kb encoding the human ATP-citrate lyase enzyme has been isolated by screening a human cDNA library with the recently isolated rat ATP-citrate lyase cDNA clone [Elshourbagy et al. (1990) J. Biol. Chem. 265, 1430]. Nucleic-acid sequence data indicate that the cDNA contains the complete coding region for the enzyme, which is 1105 amino acids in length with a calculated molecular mass of 121,419 Da. Comparison of the human and rat ATP-citrate lyase cDNA sequences… CONTINUE READING


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