Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide.

@article{Wang2009CloningAE,
  title={Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide.},
  author={Kejian Wang and Jing-jing Cai and Ling Yan Cai and H Qu and Ming Yang and Min Zhang},
  journal={Peptides},
  year={2009},
  volume={30 4},
  pages={638-46}
}
Hepcidin gene is widely expressed in various fish, suggesting that this antimicrobial peptide is a very important component in the innate immune system. Large yellow croaker (Pseudosciaena crocea) is one of the important economic species of marine-cultured fish but knowledge of its innate immune mechanism is lacking. In this study, we characterize a P. crocea hepcidin gene named as PC-hepc. It consists of an open reading frame of 258 bases encoding 85 amino acids and has a conserved sequence in… CONTINUE READING
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