Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family.

@article{Gorman1990CloningAE,
  title={Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family.},
  author={Daniel M. Gorman and Naoto Itoh and Toshio Kitamura and Jan Schreurs and Shin Yonehara and Ichiro Yahara and Ken-ichi Arai and Atsushi Miyajima},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 14},
  pages={5459-63}
}
Using a monoclonal antibody to the interleukin 3 (IL-3) receptor (anti-Aic2), we isolated a cDNA (AIC2B) from a mouse mast cell line which is homologous to the previously characterized gene for the IL-3 receptor (AIC2A). This cDNA encodes a polypeptide of 896 amino acid residues and has 91% amino acid sequence identity with the IL-3 receptor. A consensus sequence defining an additional cytokine receptor family is present in this clone. Compared to the AIC2A clone, the AIC2B cDNA encodes a… CONTINUE READING

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