Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells.

@article{McKnight1992CloningAE,
  title={Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells.},
  author={G. L. McKnight and J A Reasoner and Teresa L. Gilbert and K O Sundquist and B. K. Hokland and P A Mckernan and Josette Champagne and Carla J Johnson and Mason C. Bailey and Rick D. Holly},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 17},
  pages={12131-41}
}
Plasma membranes of cultured cells contain high affinity receptors for high density lipoprotein (HDL) that appear to mediate removal of excess intracellular cholesterol. Recent studies using ligand blot analysis have identified a 110-kDa membrane protein which has features predicted for an HDL receptor, in that it preferentially binds HDL apolipoproteins and undergoes up-regulation in response to cholesterol loading of cells. In this study, we isolated a cDNA clone from an expression library… CONTINUE READING

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