Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

@article{Gronwald1988CloningAE,
  title={Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.},
  author={R. G. K. Gronwald and F. J. Grant and Betty Haldeman and Charles E. Hart and P. J. O'Hara and Frederick S. Hagen and Russell R. Ross and Daniel F. Bowen-Pope and Merritt J. Murray},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 10},
  pages={
          3435-9
        }
}
The complete nucleotide sequence of a cDNA encoding the human platelet-derived growth factor (PDGF) receptor is presented. The cDNA contains an open reading frame that codes for a protein of 1106 amino acids. Comparison to the mouse PDGF receptor reveals an overall amino acid sequence identity of 86%. This sequence identity rises to 98% in the cytoplasmic split tyrosine kinase domain. RNA blot hybridization analysis of poly(A)+ RNA from human dermal fibroblasts detects a major (approximately 5… CONTINUE READING
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